Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Oncology --- Cancérologie --- Periodicals --- Périodiques --- Tumors --- Neoplasms --- Neoplasms. --- Tumors. --- Benign Neoplasms --- Malignancy --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Benign Neoplasm --- Cancers --- Malignancies --- Neoplasias --- Neoplasm, Benign --- Tumor --- Tumours --- Malignant Neoplasms --- Malignant Neoplasm --- Neoplasm, Malignant --- Neoplasms, Malignant --- Medical Oncology --- Pathology --- Cysts (Pathology)

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

While advances in both the treatment of cancer and the management of its complications have led to significant improvement in patient survival, infections remain a significant cause of morbidity and mortality in patients with neoplastic disease. In this patient population, infection risk results from a complex interplay between the host’s underlying immunodeficiencies, local tumor effects, and treatment-induced immunosuppression. New chemotherapeutic approaches and antimicrobial prophylaxis and treatment practices continue to shape the spectrum of infections in these patients. Clinicians who treat infections in cancer patients are continually challenged by the emergence of new pathogens and by the increasing antimicrobial resistance of established ones.   The aim of this book, is to emphasize unique aspects of management of infectious diseases in the cancer patient. With the increasing complexity of this patient population, optimal management requires a multidisciplinary approach, and this fact is fully reflected in the contributions, all from recognized authorities in the field. Ultimately, it is hoped that this volume will assist specialists in infectious diseases and haematology/oncology in the diagnosis, management, and prevention of infection and optimization of the overall care of patients with malignancies.

Cancer --- Infection. --- Complications. --- Infectious diseases --- Diseases --- Medical microbiology --- Causes and theories of causation --- Complications and sequelae --- Oncology  . --- Emerging infectious diseases. --- Hematology. --- Oncology. --- Infectious Diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Tumors --- Haematology --- Internal medicine --- Blood --- Communicable Diseases. --- Neoplasms. --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Infectious Diseases --- Communicable Disease --- Disease, Communicable --- Disease, Infectious --- Diseases, Communicable --- Diseases, Infectious --- Infectious Disease --- Disease Outbreaks --- Disease Transmission, Infectious --- Infectious diseases.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

" ... fields of oncolytic virotherapy and T cell-based therapies, Molecular Therapy-- Oncolytics considers top-quality, cutting-edge research that employs innovative molecular and cellular approaches that target cancer cells for destruction, whether by viruses, other microorganisms, vaccination, or by transfer of cells and/or genes."

Cancer --- Viruses --- Cellular therapy --- Neoplasms. --- Genetic Therapy. --- Molecular Biology. --- Cellular therapy. --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Genetic Phenomena --- DNA Therapy --- Gene Therapy, Somatic --- Genetic Therapy, Gametic --- Genetic Therapy, Somatic --- Therapy, DNA --- Therapy, Gene --- Therapy, Somatic Gene --- Gene Therapy --- Somatic Gene Therapy --- Gametic Genetic Therapies --- Gametic Genetic Therapy --- Genetic Therapies --- Genetic Therapies, Gametic --- Genetic Therapies, Somatic --- Somatic Genetic Therapies --- Somatic Genetic Therapy --- Therapies, Gametic Genetic --- Therapies, Genetic --- Therapies, Somatic Genetic --- Therapy, Gametic Genetic --- Therapy, Genetic --- Therapy, Somatic Genetic --- Gene Transfer Techniques --- Genetic Services --- Genes, Transgenic, Suicide --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Cell therapy --- Cells --- Therapy, Cellular --- Organotherapy --- Therapeutics, Physiological --- Transplantation of organs, tissues, etc. --- Cell transplantation --- Genetic vectors --- Microorganisms --- Mobile genetic elements --- Extrachromosomal DNA --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Treatment --- Therapeutic use --- Treatment. --- Therapeutic use. --- Therapy --- cell biology --- oncolytics --- molecular therapy --- gene therapy --- cancer --- Oncology. Neoplasms

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This monograph provides the first in-depth study of how mathematical and computational approaches can be used to advance our understanding of cancer therapies and to improve treatment design and outcome. Over the past century, the search for a cancer cure has been a primary occupation of medical researchers. So far, it has led to a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, and most recently, small molecule inhibitors and oncolytic viruses. Each treatment tends to have a certain effectiveness in a specific class of patients, but it is often unclear what exactly causes it to succeed or fail. Recent technological advances have given rise to an ever increasing pool of data and information that highlight the complexity underlying the cancers and their response to treatment. Next to experimental and clinical research, mathematical and computational approaches are becoming an indispensible tool to understand this complexity. Targeted Cancer Treatment in Silico is organized into two parts, corresponding to two types of targeted cancer treatment: small molecule inhibitors and oncolytic viruses. In each part, the authors provide a brief overview of the treatment’s biological basis and present the mathematical methods most suitable for modeling it. Additionally, they discuss how these methods can be applied to answer relevant questions about treatment mechanisms and propose modifications to treatment approaches that may potentially increase success rates. The book is intended for both the applied mathematics and experimental oncology communities, as mathematical models are becoming an increasingly important supplement to laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, it will be a valuable resource for scientists and graduate students alike, and can also serve as an upper-division undergraduate or graduate textbook.

Oncology. --- Cancer --- Mathematics. --- Genetics --- Physiology --- Physiological, Cellular and Medical Topics. --- Mathematical and Computational Biology. --- Genetics and Population Dynamics. --- Applications of Mathematics. --- Biological Therapy --- Computing Methodologies --- Investigative Techniques --- Laboratory Chemicals --- Drug Therapy --- Diseases --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Information Science --- Specialty Uses of Chemicals --- Chemical Actions and Uses --- Chemicals and Drugs --- Models, Theoretical --- Molecular Targeted Therapy --- Computer Simulation --- Neoplasms --- Oncolytic Virotherapy --- Small Molecule Libraries --- Biology --- Health & Biological Sciences --- Biology - General --- Research. --- Treatment --- Mathematical models --- Computerized Models --- In Silico --- Computer Models --- Models, Computer --- Computer Model --- Computer Simulations --- Computerized Model --- In Silicos --- Model, Computer --- Model, Computerized --- Models, Computerized --- Silico, In --- Silicos, In --- Simulation, Computer --- Simulations, Computer --- Chemical Libraries --- Molecular Libraries, Small --- Libraries, Chemical --- Libraries, Small Molecular --- Libraries, Small Molecule --- Molecule Libraries, Small --- Small Molecular Libraries --- Oncolytic Virus Therapy --- Virotherapy, Oncolytic --- Oncolytic Virotherapies --- Oncolytic Virus Therapies --- Therapies, Oncolytic Virus --- Therapy, Oncolytic Virus --- Virotherapies, Oncolytic --- Virus Therapies, Oncolytic --- Virus Therapy, Oncolytic --- Benign Neoplasms --- Malignancy --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Neoplasias --- Neoplasm, Benign --- Tumor --- Targeted Molecular Therapy --- Molecular Targeted Therapies --- Molecular Therapies, Targeted --- Molecular Therapy, Targeted --- Targeted Molecular Therapies --- Targeted Therapies, Molecular --- Targeted Therapy, Molecular --- Therapies, Molecular Targeted --- Therapies, Targeted Molecular --- Therapy, Molecular Targeted --- Therapy, Targeted Molecular --- Experimental Model --- Experimental Models --- Mathematical Model --- Model, Experimental --- Models (Theoretical) --- Models, Experimental --- Models, Theoretic --- Theoretical Study --- Mathematical Models --- Model (Theoretical) --- Model, Mathematical --- Model, Theoretical --- Models, Mathematical --- Studies, Theoretical --- Study, Theoretical --- Theoretical Model --- Theoretical Models --- Theoretical Studies --- Specialty Chemicals and Products --- Information Sciences --- Science, Information --- Sciences, Information --- Therapy --- Therapeutic --- Therapies --- Treatments --- Disease --- Therapy, Drug --- Chemotherapy --- Pharmacotherapy --- Chemotherapies --- Drug Therapies --- Pharmacotherapies --- Therapies, Drug --- Pharmaceutical Preparations --- Chemicals, Laboratory --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- High Performance Computing --- Methodologies, Computing --- Computing Methodology --- Computing, High Performance --- Methodology, Computing --- Performance Computing, High --- Biologic Therapy --- Biotherapy --- Therapy, Biological --- Biologic Therapies --- Biological Therapies --- Biotherapies --- Therapies, Biologic --- Therapies, Biological --- Therapy, Biologic --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Animal physiology --- Animals --- Math --- Cancer research --- therapy --- drug therapy --- therapeutic use --- Cancer research. --- Applied mathematics. --- Engineering mathematics. --- Biomathematics. --- Cancer Research. --- Mathematical models. --- Oncology  . --- Science --- Anatomy --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Mathematics --- Engineering --- Engineering analysis --- Mathematical analysis